By David Schiff, Santosh Kesari, Patrick C. Y. Wen
Neuro-oncology has advanced considerably as a medical and learn self-discipline during the last few a long time. Cancer Neurology in medical perform: Neurologic issues of melanoma and its therapy, moment Edition presents clinicians from numerous backgrounds and degrees of teaching with a connection with support concentration the differential prognosis, remedy approach, and administration plan for the melanoma sufferer with neurologic indicators and findings.
The quantity starts off with an outline of the sphere of neuro-oncology and a evaluate of the function of neuroimaging within the analysis of neuro-oncologic illness. a number of chapters on interpretation and administration of universal neuro-oncologic indicators persist with. next sections include chapters at the direct and oblique neurologic issues of melanoma in addition to problems of remedy. the ultimate part makes a speciality of the spectrum and administration of neurologic ailment in sufferers with melanoma of particular organs.
Cancer Neurology in scientific perform: Neurologic issues of melanoma and its therapy, moment Edition is a vital new paintings that goals to develop and deepen the familiarity of clinicians with the variety and administration of neuro-oncologic ailments so one can enhance the standard of take care of melanoma patients.
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Additional info for Cancer Neurology in Clinical Practice; Neurologic Complications of Cancer and Its Treatment
When focal seizures occur in the setting of an underlying brain tumor, associated focal neurologic findings are also generally present (11,49–54). Conversely, prolonged or permanent focal deficits can occur in patients with brain tumors following seizures of focal onset (22,63). Similarly, prolonged or irreversible cognitive decline may occur following generalized seizures in brain tumor patients. Seizure-induced increases in intracranial pressure, disruption of the blood–brain barrier, and elevations in excitotoxic neurotransmitter levels superimposed upon pre-existing abnormalities in intracranial pressure, blood flow, and the peritumoral microenvironment may provide a physiologic explanation for these observations (64,65).
There are several explanations for the failure of surgery to eliminate seizures in all patients. Incomplete tumor resection is the most obvious reason. The development of post-surgical seizure foci related to reactive changes and scarring, or to tumor recurrence, represent additional common explanations. Another possibility for the persistence of seizures despite a gross total tumor resection is that the offending epileptogenic focus or foci are frequently located at considerable distance from the tumor, in completely tumor-free areas of brain (138).
G.. heparin) related Disseminated intravascular coagulation Tumor-Related New or progressive disease Including neoplastic meningitis and brain metastases Paraneoplastic Encephalitis (68,157) Increasingly recognized; most common with small cell lung cancer and ovarian teratoma Other Posterior Reversible Leukoencephalopathy Syndrome (158) Seen in multiple settings, including bone marrow transplant, immunosuppressive therapy with cyclosporin, tacrolimus, interferon- and others. Abrupt increases in blood pressure may predispose.
Cancer Neurology in Clinical Practice; Neurologic Complications of Cancer and Its Treatment by David Schiff, Santosh Kesari, Patrick C. Y. Wen