Download Bioinformatics: Sequence, Structure and Databanks by D. Higgins, Willie Taylor PDF

By D. Higgins, Willie Taylor

ISBN-10: 0199637911

ISBN-13: 9780199637911

Bioinformatics covers sensible vital themes within the research of protein sequences and constructions. It contains evaluating amino acid sequences to buildings evaluating constructions to one another, looking info on whole protein households in addition to looking out with unmarried sequences, the best way to use the net and the way to establish and use the SRS molecular biology database administration approach. eventually, there are chapters on a number of series alignment and protein secondary constitution prediction. Bioinformatics can be precious to occasional clients of those innovations in addition to skilled execs or researchers.

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Extra resources for Bioinformatics: Sequence, Structure and Databanks

Sample text

COMPARISON OF PROTEIN THREE-DIMENSIONAL STRUCTURES fS-strands, matching closely and sequentially along the fold of the two structures. Differences in Ca-atom traces arc more often seen at loop regions that connect the strands and helices in proteins: Frequently these loop regions are exposed to the solvent at the surface of the protein and thus have fewer constraints placed on their conformations. For more dissimilar protein structures, rigid body movements and other structural changes can occur in one structure relative to the other.

B. and Barton, G. J. (1994). Structural features can be unconserved in proteins with similar folds—an analysis of side-chain to side-chain contacts, secondary structure and accessibility. J. Mol. , 244, 332. 18. Orengo, C. , Jones, D. , and Thornton, J. M. (1994). Protein superfamilies and domain superfolds. Nature, 372, 631. 19. Kraulis, P. J. (1991). Molscript—a program to produce both detailed and schematic plots of protein structures. J . Appl. , 24, 946. 20 Jones, D. , and Thornton, J. M. (1996).

2. Godzik, A. and Skolnick, J. (1992). Sequence-structure matching in globular proteins: Application to supersecondaiy and tertiary structure determination. Proc. Nail. Acad. Set USA, 89,12098. 12 THREADING METHODS FOR PROTEIN STRUCTURE PREDICTION 3. , and Schneider, R. (1993). Prediction of protein structure by evaluation of sequence-structure fitness. J. Mol. , 232, 805. 4. , and Argos, P. (1994). Recognition of distantly related proteins through energy calculations. Proteins: Struct, Funct. , 19, 132.

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Bioinformatics: Sequence, Structure and Databanks by D. Higgins, Willie Taylor


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