By Teresa K. Attwood, Stephen R. Pettifer, David Thorne
This cutting edge ebook presents a totally clean exploration of bioinformatics, investigating its advanced interrelationship with biology and desktop technology. It ways bioinformatics from a special viewpoint, highlighting interdisciplinary gaps that regularly capture the unwary.
The booklet considers how the necessity for organic databases drove the evolution of bioinformatics; it stories bioinformatics fundamentals (including database codecs, data-types and present research methods), and examines key issues in machine technological know-how (including data-structures, identifiers and algorithms), reflecting on their use and abuse in bioinformatics.
Bringing those disciplines jointly, this e-book is a necessary learn in the event you desire to higher comprehend the demanding situations for bioinformatics on the interface of biology and desktop technology, and the way to bridge the gaps. it is going to be a useful source for complicated undergraduate and postgraduate scholars, and for teachers, researchers and execs with an curiosity during this attention-grabbing, fast-moving self-discipline and the knotty difficulties that encompass it.
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Extra resources for Bioinformatics challenges at the interface of biology and computer science: mind the gap
10 Bioinformatics challenges at the interface of biology and computer science represent increasingly complex and sophisticated things. Using a computer to calcu late mathematical results is, in some ways, easy – this, after all, is what computers do. Determining which book someone is likely to want to buy next, based on the reading habits of people who have been established as having similar tastes, or – to bring this technological tale back to the life sciences – predicting whether individuals are likely to suffer from particular diseases, based on their genetic profiles, are altogether much more complex problems for computers to solve.
Journal of Molecular Evolution, 26, 34–46. Zuckerkandl, E. and Pauling, L. (1965) Molecules as documents of evolutionary history. Journal of Theoretical Biology, 8, 357–366. 7 Quiz The following multiple‐choice quiz will help you to check how much you’ve remem bered of the origins of bioinformatics and computer science described in this chapter. Be mindful that in this and other quizzes throughout the book – just to keep you on your toes – there may be more than one answer! 1 Who first introduced the term bioinformatics?
P. and Kitai, R. (1955) The amide groups of insulin. Biochemical Journal, 59(3), 509–518. F. (1990) The history of the genetic sequence databases. Genomics, 6, 701–707. H. and Moore, S. (1963) The sequence of amino acid residues in bovine pancreatic ribonuclease: revisions and confirmations. Journal of Biological Chemistry, 238, 227–234. Strasser, B. (2008) GenBank – Natural history in the 21st century? Science, 322, 537–538. Wallace, W. (2001) Bioinformatics: key to 21st century biology. BioMedNet, issue 99, 30 March 2001.
Bioinformatics challenges at the interface of biology and computer science: mind the gap by Teresa K. Attwood, Stephen R. Pettifer, David Thorne