By Andrzej Polanski
This textbook offers mathematical types in bioinformatics and describes organic difficulties that encourage the pc technological know-how instruments used to control the large information units concerned. the 1st a part of the e-book covers mathematical and computational tools, with sensible purposes awarded within the moment half. The mathematical presentation avoids pointless formalism, whereas closing transparent and exact. The ebook closes with a radical bibliography, attaining from vintage learn effects to very fresh findings. This quantity is suited to a senior undergraduate or graduate path on bioinformatics, with a powerful specialize in mathematical and computing device technological know-how background.
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Extra resources for Bioinformatics
6 The Expectation Maximization Method 43 Mixture Distributions Mixtures of distributions are often applied to model or investigate the underlying structure in experimental data . Mixture distributions have the form K f mix (x, α1 , . . , αK , p1 , . . 77) k=1 where α1 , . . , αK , p1 , . . , pK are the parameters of the mixture distribution. The weights (probabilities) α1 , . . 78) k=1 and the fk (x, pk ) are probability density functions. K with probabilities α1 , . . , αK , and (2) Generate a number (or vector) x from the probability distribution fk (x, pk ).
Pn relative to the distribution q1 , q2 , . . , qn . 67) and KX,Y = 0 ⇔ fX (z) = fY (z) (possibly except for a set of measure zero). 40 2 Probability and Statistics EM Recursions Let us assume that the available observation (or observations) is modeled by a random variable (or random vector) X and that the aim is to estimate the parameter (or parameter vector) p. Also, we assume there exist some missing observations X m . By merging available and missing observations we obtain X c = (X m , X) called the complete observations.
KM ) = pk1 pk2 . . k2 ! . kM ! 1 2 where k1 , k2 , . . , kM are counts of outcomes and M m=1 km = K. 6 The Hypergeometric Distribution The Hypergeometric distribution describes the number of successes in random sampling, without replacement, from a ﬁnite population with two types of individuals, 1 and 0. For a hypergeometrically distributed random variable X, with parameters N , M , n, the event [X = k] is interpreted as k characters of type 1 in a sample of size n, drawn randomly from a ﬁnite population of N individuals, of which M are of type 1 and N −M of type 0.
Bioinformatics by Andrzej Polanski